Figure 29: Is ICSI used only for couples diagnosed with male factor infertility?

Figure 29 is a pie chart representing use of ICSI (intracytoplasmic sperm injection) in fresh–nondonor cycles among couples with and without diagnoses of male factor infertility, 2005. Note: This is based on 58,079 cycles that used IVF with ICSI.

• ICSI use among couples diagnosed with male factor infertility, 50.4%
• ICSI use among couples without a diagnosis of male factor infertility, 49.6%

Figure 30: What are the success rates for couples with male factor infertility when ICSI is used?

Figure 30 is a bar graph representing percentages of retrievals that resulted in live births among couples diagnosed with male factor infertility who used IVF with ICSI (intracytoplasmic sperm injection), compared with couples not diagnosed with male factor infertility who used IVF without ICSI, by woman’s age, 2005. Note: Cycles using donor sperm and cycles using GIFT or ZIFT are excluded.

• Age <35, IVF with ICSI among couples with male factor infertility 41.0%, IVF without ICSI among couples with no male factor infertility 43.6%
• Age 35–37, IVF with ICSI among couples with male factor infertility 34.4%, IVF without ICSI among couples with no male factor infertility 35.9%
• Age 38–40, IVF with ICSI among couples with male factor infertility 23.5%, IVF without ICSI among couples with no male factor infertility 26.2%
• Age 41–42, IVF with ICSI among couples with male factor infertility 13.0%, IVF without ICSI among couples with no male factor infertility 14.0%
• Age >42, IVF with ICSI among couples with male factor infertility 5.1%, IVF without ICSI among couples with no male factor infertility 5.4%

Figure 31: What are the success rates for couples without a diagnosis of male factor infertility when ICSI is used?

Figure 31 is a bar graph representing percentages of retrievals that resulted in live births among couples not diagnosed with male factor infertility, by use of ICSI (intracytoplasmic sperm injection) and woman’s age, 2005. Note: Cycles using donor sperm and cycles using GIFT or ZIFT are excluded.

• Age <35, IVF with ICSI among couples with no male factor infertility 38.0%, IVF without ICSI among couples with no male factor infertility 43.6%
• Age 35–37, IVF with ICSI among couples with no male factor infertility 30.8%, IVF without ICSI among couples with no male factor infertility 35.9%
• Age 38–40, IVF with ICSI among couples with no male factor infertility 20.6%, IVF without ICSI among couples with no male factor infertility 26.2%
• Age 41–42, IVF with ICSI among couples with no male factor infertility 12.6%, IVF without ICSI among couples with no male factor infertility 14.0%
• Age >42, IVF with ICSI among couples with no male factor infertility 4.5%, IVF without ICSI among couples with no male factor infertility 5.4%

Figure 32: How many embryos are transferred in an ART procedure?

Figure 32 is a pie chart representing the number of embryos transferred during ART cycles using fresh nondonor eggs or embryos, 2005. Note: Total does not equal 100% due to rounding.

• One, 9.3%
• Two, 43.4%
• Three, 29.4%
• Four, 12.0%
• Five, 3.9%
• Six, 1.3%
• Seven or more, 0.6%

Figure 33: In general, is an ART cycle more likely to be successful if embryos are transferred?

Figure 33 is a bar graph representing percentages of transfers that resulted in live births and the percentages of multiple-infant live births for ART cycles using fresh nondonor eggs or embryos, by number of embryos transferred, 2005. Note: In rare cases a single embryo may divide and thus produce twins. For this reason, a small percentage of twins resulted from a single embryo transfer, and a small percentage of triplets resulted when two embryos were transferred. Totals do not equal 100% due to rounding.

• 1 embryo transferred: Percentage of transfers that resulted in live births 16.7%. Of these live births, 98.0% were singletons and 2.0% were twins.
• 2 embryos transferred: Percentage of transfers that resulted in live births 40.9%. Of these live births, 66.7% were singletons, 32.4% were twins and 0.8% were triplets or more.
• 3 embryos transferred: Percentage of transfers that resulted in live births 34.3%. Of these live births, 65.8% were singletons, 29.8% were twins and 4.5% were triplets or more.
• 4 embryos transferred: Percentage of transfers that resulted in live births 29.9%. Of these live births, 67.1% were singletons, 27.9% were twins and 5.0% were triplets or more.
• 5 or more embryos transferred: Percentage of transfers that resulted in live births 22.9%. Of these live births, 68.5% were singletons, 27.5% were twins and 4.0% were triplets or more.

Figure 34: Are success rates affected by the number of embryos transferred for women who have more embryos available than they choose to transfer?

Figure 34 is a bar graph representing percentages of transfers that resulted in live births and percentages of multiple-infant live births for ART cycles in women who were younger than 35, used fresh nondonor eggs or embryos, and set aside extra embryos for future use, by number of embryos transferred, 2005. Note: In rare cases, a single embryo may divide and thus produce twins. For this reason, a small percentage of twins resulted from a single embryo transfer and a small percentage of triplets resulted when two embryos were transferred. Totals do not all equal 100% due to rounding.

• 1 embryo transferred: Percentage of transfers that resulted in live births 43.3%. Of these live births, 98.0% were singletons, 1.9% were twins.
• 2 embryos transferred: Percentage of transfers that resulted in live births 52.8%. Of these live births, 60.2% were singletons, 38.6% were twins and 1.2% were triplets or more.
• 3 embryos transferred: Percentage of transfers that resulted in live births 47.5%. Of these live births, 55.5% were singletons, 36.0% were twins and 8.5% were triplets or more.
• 4 embryos transferred: Percentage of transfers that resulted in live births 45.8%. Of these live births, 54.1% were singletons, 32.4% were twins and 13.5% were triplets or more.
• 5 or more embryos transferred: Percentage of transfers that resulted in live births 41.8%. Of these live births, 48.8% were singletons, 39.0% were twins and 12.2% were triplets or more.
 

Figure 35: How long after egg retrieval does embryo transfer occur?

Figure 35 is a pie chart representing the day of embryo transfer among ART cycles using fresh nondonor eggs or embryos, 2005. Note: Day of embryo transfer is defined as the number of days following egg retrieval. Cycles using GIFT or ZIFT are excluded. Missing or implausible values for day of embryo transfer (i.e., 0 or >6) are not included in these statistics. Total does not equal 100% due to rounding.

• Day 1, 0.1%
• Day 2, 3.7%
• Day 3, 67.4%
• Day 4, 3.6%
• Day 5, 23.1%
• Day 6, 2.0%

Figure 36: In general, is an ART cycle more likely to be successful if embryos are transferred on day 5?

Figure 36 is a bar graph representing percentages of day 3 and day 5 embryo transfers using fresh nondonor eggs or embryos that resulted in live births, by woman’s age, 2005. Note: Cycles using GIFT or ZIFT are excluded. This comparison is limited to transfers on day 3 and day 5. Embryo transfers performed on days 1, 2, 4, and 6 are not included because each of these accounted for a small proportion of procedures.

• Age <35, Day 3, 40.9%, Day 5, 50.5%
• Age 35–37, Day 3, 34.5%, Day 5, 41.8%
• Age 38–40, Day 3, 24.1%, Day 5, 33.5%
• Age 41–42, Day 3, 14.2%, Day 5, 21.0%
• Age >42, Day 3, 5.2%, Day 5, 11.2%
 

Figure 37: Does the number of embryos transferred differ for day 3 and day 5 embryo transfers?

Figure 37 consists of two pie charts representing the number of embryos transferred during ART cycles using fresh nondonor eggs or embryos for day 3 and day 5 embryo transfers, 2005. Note: Cycles using GIFT or ZIFT are excluded. This comparison is limited to transfers on day 3 and day 5. Embryo transfers performed on days 1, 2, 4, and 6 are not included because each of these accounted for a small proportion of procedures. Totals do not equal 100% due to rounding.

• Day 3:
  • 1 embryo transferred, 8.3%
  • 2 embryos transferred, 35.4%
  • 3 embryos transferred, 34.1%
  • 4 or more embryos transferred, 22.3%
• Day 5:
  • 1 embryo transferred, 9.8%
  • 2 embryos transferred, 67.8%
  • 3 embryos transferred, 17.2%
  • 4 or more embryos transferred, 5.3%
     

Figure 38: In general, how does the multiple-infant birth risk vary by the day of embryo transfer?

Figure 38 depicts two pie charts, A and B, representing the risks of having multiple-infant live births for ART cycles using fresh nondonor eggs or embryos for day 3 and day 5 embryo transfers, 2005. Note: Cycles using GIFT or ZIFT are excluded. This comparison is limited to transfers on day 3 and day 5. Embryo transfers performed on days 1, 2, 4, and 6 are not included because each of these accounted for a small proportion of procedures. Totals do not equal 100% due to rounding.

• Pie chart A represents 16,813 live births for day 3 embryo transfers
  • Singletons: 69.3%
  • Total multiple-infant live births 30.6%, which is subdivided as follows:
    • Twins: 27.8%
    • Triplets or more: 2.8%
• Pie chart B represents 7,947 live births for day 5 embryo transfers
  • Singletons: 64.3%
  • Total multiple-infant live births 35.7%, which is subdivided as follows:
    • Twins: 34.1%
    • Triplets or more: 1.6%

Figure 39: For day 5 embryo transfers, are success rates affected by the number of embryos transferred for women who have more embryos available than they choose to transfer?

Figure 39 is a bar graph representing the percentages of transfers that resulted in live births and percentages of multiple-infant live births for Day 5 embryo transfers among women who were younger than 35, used fresh nondonor eggs or embryos, and set aside extra embryos for future use, by number of embryos transferred, 2005. Note: In rare cases, a single embryo may divide and thus produce twins. For this reason, a small percentage of twins resulted from a single embryo transfer and a small percentage of triplets resulted when two embryos were transferred.

• 1 embryo transferred: Percentage of transfers that resulted in live births 48.2%. Of these live births, 97.2% were singletons, 2.8% were twins.
• 2 embryos transferred: Percentage of transfers that resulted in live births 57.5%. Of these live births, 56.3% were singletons, 42.3% were twins and 1.4% were triplets or more.
• 3 or more embryos transferred: Percentage of transfers that resulted in live births 44.0%. Of these live births, 51.1% were singletons, 36.8% were twins and 12.1% were triplets or more.

Figure 40: What are the success rates for women who use gestational carriers?

Figure 40 is a bar graph representing a comparison of percentages of transfers that resulted in live births between cycles that used gestational carriers and those that did not (both using fresh nondonor embryos), by ART patient’s age, 2005. Note: Age categories reflect the age of the ART patient, not the age of the gestational carrier.

• Age <35, Used a gestational carrier 47.8%, Did not use a gestational carrier 43.3%
• Age 35–37, Used a gestational carrier 39.2%, Did not use a gestational carrier 35.9%
• Age 38–40, Used a gestational carrier 30.7%, Did not use a gestational carrier 25.4%
• Age >40, Used a gestational carrier 11.0%, Did not use a gestational carrier 11.8%

Note: We were unable to further subdivide Age >40 because the number of such cycles is very small.

Figure 41: How is clinic size related to success rates?

Figure 41 is a bar graph representing percentages of ART cycles using fresh nondonor eggs or embryos that resulted in live births, by clinic size, 2005. Note: Clinic size is determined by the number of cycles performed in 2005.

• Clinic size <66 cycles performed, 28.7%
• Clinic size 66–123 cycles performed, 26.5%
• Clinic size 124–260 cycles performed, 28.5%
• Clinic size >260 cycles performed, 27.7%

Section 1 | Section 2 | Section 3 | Section 4 | Section 5

Previous ART Reports

Implementation of the Fertility Clinic Success Rate and Certification Act of 1992

Assisted Reproductive Technology: Embryo Laboratory