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A cluster of patients with a chronic mononucleosis-like syndrome
Holmes GP, Kaplan JE, Stewart JA, Hunt B, Pinsky PF, Schonberger LB.A cluster of patients with a chronic mononucleosis-like syndrome.
JAMA 257:2297-2302, 1987.
Summary
This is the first published article of the CDC CFS Research Program and reports the findings of our investigation of fatiguing illness in Incline Village, NV.
Abstract
A cluster of 134 patients who had undergone Epstein-Barr virus (EBV) serological testing because of suspected chronic EBV syndrome was investigated in Nevada. Fifteen case-patients were identified who had severe, persistent fatigue of underdetermined etiology for more than two months. When compared with the remaining 119 patients who had less severe illnesses and with 30 age-sex-, and race-matched control-persons, these 15 patients had significantly higher antibody titers against various components of EBV and against cytomegalovirus and herpes simplex and measles viruses. EBV serology could not reliably differentiate individual case-patients from the others, and the reproducibility of the tests within and among laboratories was poor. As a group, the case-patients appear to have had a syndrome that is characterized by chronic fatigue, fever, sore throat, and lymphadenopathy. The relationship of this fatigue syndrome to EBV is unclear; further studies are needed to determine its etiology.
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